Sinclair Method Studies
This article examines the scientific foundation behind TSM, drawing on nearly three decades of peer‑reviewed trials, neuroimaging research, and systematic reviews.
Is Naltrexone Available in the UK and Ireland? What You Need to Know
Naltrexone is a non-addictive opioid antagonist that blocks the brain’s ability to feel pleasure from alcohol. Over time, drinking becomes less rewarding, reducing cravings and consumption naturally — a process known as Pharmacological Extinction. This effect is the foundation of The Sinclair Method (TSM), where individuals take Naltrexone only prior to drinking, gradually reprogramming their brain’s response to alcohol.
The Sunday Reset
Every Sunday, we share a 2-minute insight into the logic of the Sinclair Method.
Join thousands of others for our weekly newsletter and change how you see the problem,
because when you change the way you look at things, the things you look at change.
… There’s a reason we’re called Rethink Drink!
